Reports

Hurler and Hunter Syndromes: Mutual Correction of the Defect in Cultured Fibroblasts

Science  01 Nov 1968:
Vol. 162, Issue 3853, pp. 570-572
DOI: 10.1126/science.162.3853.570

Abstract

The biochemical defect of cultuired skin fibroblasts from Hurler or Hunter patients (faulty degradation of sulfated mucopolysaccharide, resulting in excessive intracellular accumulation) may be corrected if cells of these two genotypes are mixed with each other or with normal cells. The effect is mediated by substances released into the medium.

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