C'3 Synthesis in the Human Fetus and Lack of Transplacental Passage

Science  08 Nov 1968:
Vol. 162, Issue 3854, pp. 672-673
DOI: 10.1126/science.162.3854.672


Allotypic differences in the third component of complement between mothers and their newborns provided evidence for synthesis of this complement component by the fetus. There was no indication that this protein traversed the placenta. The known low level of C'3 in the neonate was confirmed, and the maternal concentration was found to be significantly elevated.