Hepatic Microsomal Enzymes in Man and Rat: Induction and Inhibition by Ethanol

Science  08 Nov 1968:
Vol. 162, Issue 3854, pp. 690-691
DOI: 10.1126/science.162.3854.690


The feeding of ethanol increased significantly the activities of hepatic pentobarbital and benzpyrene hydroxylases in rats, and, in human volunteers, doubled pentobarbital hydroxylase activity. In vitro ethanol inhibited aniline, pentobarbital, and benzpyrene hydroxylases. These data may explain, at least in part, the increased tolerance of alcoholics to sedatives when sober, and the enhanced sensitivity to sedatives when inebriated.