Partial Resolution of DL-Adenosine by Template Synthesis

Science  15 Nov 1968:
Vol. 162, Issue 3855, pp. 809-810
DOI: 10.1126/science.162.3855.809


D-Adenosine-5'-phosphorimidazolide reacts very much more rapidly with D-adenosine than with L-adenosine on a poly-D-uridylic acid template. This permits the partial resolution of DL-adenosine. These experiments suggest that segregation of D- and L-nucleotides may have occurred at an early stage in biochemical evolution.