Reports

Erythropoiesis in the Rat: Differential Rates of DNA Synthesis and Cell Proliferation

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Science  06 Dec 1968:
Vol. 162, Issue 3858, pp. 1132-1134
DOI: 10.1126/science.162.3858.1132

Abstract

Direct in vivo estimates of DNA synthesis time in early and late erythroblasts were obtained by using the H3- and C14-thymidine double-la-beling technique. A double-emulsion autoradiographic procedure was used to resolve the two isotopes. Early erythroblasts were found to proliferate at a rate about five times that of late cells. This results primarily from a shorter mean DNA synthesis time in early cells (2.5 hours) than in late cells (6.5 hours).