Reports

Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine

+ See all authors and affiliations

Science  13 Dec 1968:
Vol. 162, Issue 3859, pp. 1290-1292
DOI: 10.1126/science.162.3859.1290

Abstract

Tolerance and physical dependence development to morphine in mice can be prevented by concomitant administration of cycloheximide. The fact that the rate of synthesis of brain 5-hydroxytryptamine (5HT) increases with tolerance to morphine suggests that the protein involved may be associated with 5HT synthesis. Inhibition of this synthesis with p-chlorophenylalanine markedly decreases tolerance and physical dependence development to morphine.

Related Content