Induction of Brain D(m)-β-Hydroxybutyrate Dehydrogenase Activity by Fasting

Science  03 Jan 1969:
Vol. 163, Issue 3862, pp. 79-81
DOI: 10.1126/science.163.3862.79


D(m)-β-hydroxybutyrate dehydrogenase activity is very low in normal adult rat brain; but during fasting it increases severalfold in parallel with the ketosis. The increase may represent part of a mechanism by which the brain adapts to changing patterns of substrate supply during starvation.