Giant Hepatic Mitochondria: Production in Mice Fed with Cuprizone

Science  03 Jan 1969:
Vol. 163, Issue 3862, pp. 81-82
DOI: 10.1126/science.163.3862.81


Giant mitochondria in hepatocytes that have the average size of nuclei can be consistently produced in the liver of weanling mice by feeding them cuprizone (bis-cyclohexanone oxaldihydrazone). The simplicity of the procedure and the consistency of the results make the feeding of cuprizone a new and useful experimental tool for the study of mitochondrial metabolism.