Cycasin: Detection of Associated Mutagenic Activity in vivo

Science  14 Feb 1969:
Vol. 163, Issue 3868, pp. 689-691
DOI: 10.1126/science.163.3868.689


Cycasin and its lagycone, methylazoxymethanol, increase the mutant frequency of Salmonella typhimurium histidine auxotrophs when tested in the hostmediated assay. As expected, the degree of cycasin-related mutagenic activity depends on the facility with which the compound can be enzymatically deglucosylated by the normal intestinal flora.