Reports

Serum C'3 Lytic System in Patients with Glomerulonephritis

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Science  25 Apr 1969:
Vol. 164, Issue 3878, pp. 436-437
DOI: 10.1126/science.164.3878.436

Abstract

The serums of patients with hypocomplementemic glomerulonephritis contain a substance that combines with a normal serum cofactor in the presence of magnesium ion to specifically cleave the third component of complement. This lysis of C'3 is 80 to 90 percent complete in 20 minutes at 37°C and pH 7. Neither the nephritic factor nor its cofactor is identifiable with the complement system.