Plasma Saluretic Activity: Its Nature and Relation to Oxytocin Analogs

Science  02 May 1969:
Vol. 164, Issue 3879, pp. 580-582
DOI: 10.1126/science.164.3879.580


Plasma natriuretic activity was evoked in cows and dogs by infusion of saline with or without dextran. Deproteinized samples were fractionated on both Sephadex and Bio-Gel columns; the activity was separated, the approximate molecular weight being in the region of 1000. Incubation with chymotrypsin destroyed the activity, suggesting that it might be a polypeptide. A similar activity in blood resulted from intracarotid injection of either oxytocin or either of two synthetic analogs. Possibly the latter are saluretic by virtue of a releasing action on some intracranial structure for another natriuretic peptide.