Collagen Gels: Design for a Vitreous Replacement

Science  13 Jun 1969:
Vol. 164, Issue 3885, pp. 1282-1283
DOI: 10.1126/science.164.3885.1282


Clear, stable gels have been prepared from purified tropocollagen from calf skin; the collagen was solubilized with a proteolytic enzyme (Proctase) and stabilized by ultraviolet irradiation under nitrogen. These gels are clear, possess altered immunologic reactivity, and have properties of an ideal vitreous replacement. Implantations in rabbit and monkey eyes appear to be well tolerated, remain clear, and gradually disappear in about 2 months.