Limited Periods of Gene Expression in Immunoglobulin-Synthesizing Cells

Science  27 Jun 1969:
Vol. 164, Issue 3887, pp. 1524-1525
DOI: 10.1126/science.164.3887.1524


In synchronized human lymphoid cell lines, production of immunoglobulins G and M is greatest during the late Gl and S phases of the cell cycle. Little immunoglobulin appears immediately before, during, and immediately after mitosis. The results indicate that transcription of immunoglobulin genes takes place during a limited part of the mitotic cycle.