Adenosine 3',5'-Monophosphate-Dependent Protein Kinase from Brain

Science  04 Jul 1969:
Vol. 165, Issue 3888, pp. 63-65
DOI: 10.1126/science.165.3888.63


Adenosine 3',5'-monophosphate at a concentration of 5 x 10-7 mole per liter causes a 400 percent increase in the rate of phosphorylation of histone catalyzed by a partially purified enzyme preparation from rabbit brain. The data provide the first direct evidence of a biochemical action of adenosine 3',5'-monophosphate in the brain.