Transplantation of Pluripotential Nuclei from Triploid Frog Tumors

Science  25 Jul 1969:
Vol. 165, Issue 3891, pp. 394-396
DOI: 10.1126/science.165.3891.394


Renal tumors were produced by injection of a cell fraction of a tumor into triploid tadpoles of Rana pipiens before they began feeding. Triploid tumor cells were dissociated and transplanted into activated and enucleated eggs. Pluripotency of the implanted nuclei was evidenced by the formation of swimming triploid tadpoles.