Toad Urinary Bladder: Intercellular Spaces

Science  01 Aug 1969:
Vol. 165, Issue 3892, pp. 503-504
DOI: 10.1126/science.165.3892.503


Vasopressin causes dilation of the intercellular spaces of the mucosal epithelium in toad bladder, an effect previously thought to result from enhanced net transepithelial water transport. Under conditions of zero net fluid transport, vasopressin exerted the same effect in seven tissues, which indicates that the width of the intercellular spaces cannot be taken as a reliable index of net transepithelial fluid transport.