Human Growth Hormone Release: Relation to Slow-Wave Sleep and Sleep-Waking Cycles

Science  01 Aug 1969:
Vol. 165, Issue 3892, pp. 513-515
DOI: 10.1126/science.165.3892.513


Release of human growth hormone during sleep is significantly related to slow, synchronized stages of sleep and therefore would seem to be controlled by related neural mechanisms. When sleep-waking cycles are reversed by 12 hours, the release of growth hormone with sleep is reversed; thus release does not follow an inherent circadian rhythm independent of sleep.