Reports

Oxygen-Hemoglobulin Dissociation Curves: Effect of Inherited Enzyme Defects of the Red Cell

Science  08 Aug 1969:
Vol. 165, Issue 3893, pp. 601-602
DOI: 10.1126/science.165.3893.601

Abstract

The blood of a patient with a deficiency of hexokinase in the red cells and a decreased concentration of 2, 3-diphosphoglycerate in the red cells showed an increased affinity for oxygen, whereas a patient with a deficiency of pyruvate kinase and an elevated concentration of 2, 3-diphosphoglycerate in the red cells had blood with a decreased affinity for oxygen. Defects in red cell glycolysis may alter the oxygen affinity of blood by virtue of their effect on 2, 3-diphosphoglycerate concentrations in red cells.

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