Serum Elastase Inhibitor Deficiency and αl-Antitrypsin Deficiency in Patients with Obstructive Emphysema

Science  15 Aug 1969:
Vol. 165, Issue 3894, pp. 709-710
DOI: 10.1126/science.165.3894.709


A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with α1-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.