Reports

Sarcoma-Producing Cell Lines Derived from Clones Transformed in vitro by Benzo[a]pyrene

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Science  29 Aug 1969:
Vol. 165, Issue 3896, pp. 917-918
DOI: 10.1126/science.165.3896.917

Abstract

Cells derived from mixed Syrian hamster embryo cultures were treated with pyrene (control) or with benzo[a]pyrene. Transformed clones were obtained only with the carcinogen. Some of the transformed clones were responsible for cell lines that produced tumors when injected into hamsters. These observations provide evidence that chemical-induced oncogenesis can be studied by an in vitro model.