Reports

Cytogenetic Studies in Rats of Cyclohexylamine, a Metabolite of Cyclamate

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Science  12 Sep 1969:
Vol. 165, Issue 3898, pp. 1139-1140
DOI: 10.1126/science.165.3898.1139

Abstract

Cyclohexylamine, the major known metabolite of cyclamate, was tested in vivo for possible cytogenetic effects. In rats injected with this metabolite, there was a direct relation between dose concentration and percentage of spermatogonial and bone marrow cells showing chromosomal breaks. Single chromatid breaks predominated with infrequent exchange figures.