Reports

Puromycin: Effect on Memory of Mice When Injected with Various Cations

Science  12 Sep 1969:
Vol. 165, Issue 3898, pp. 1143-1144
DOI: 10.1126/science.165.3898.1143

Abstract

Puromycin dihydrochloride neutralized with bases of potassium, lithium, calcium, or magnesium fails to block expression of memory of maze learning in mice, unlike puromycin neutralized with NaOH. This failure may be due to cationic binding at anionic membrane sites with a resultant exclusion of sufficient peptidyl-puromycin to make it ineffective in blocking memory.

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