Lysergic Acid Diethylamide: Role in Conversion of Plasma Tryptophan to Brain Serotonin (5-Hydroxytryptamine)

Science  10 Oct 1969:
Vol. 166, Issue 3902, pp. 237-239
DOI: 10.1126/science.166.3902.237


Injections of D-lysergic acid diethylamide decrease the turnover rate of 5-hydroxytryptamine of rat brain, as measured from the conversion of 14C-tryptophan into 14C-5-hydroxytryptamine. The 2-bromolysergic acid diethylamide given in doses fivefold greater than those of lysergic acid diethylamide fails to change the rate of 14C-tryptophan conversion into 14C-5-hydroxytryptamine. The effect of D-lysergic acid diethylamide is discussed with regard to its action on brain serotonergic neurons and its psychotomimetic effects.