Brain Lesions in an Infant Rhesus Monkey Treated with Monosodium Glutamate

Science  17 Oct 1969:
Vol. 166, Issue 3903, pp. 386-388
DOI: 10.1126/science.166.3903.386


In an infant rhesus monkey brain damage resulted from subcutaneously administered monosodium glutamate. Although a relatively high dose of monosodium glutamate was used, the infant was asymptomatic for a 3-hour observation period during which time hypothalamic neurons were undergoing a process of acute cell death. With the electron microscope it was observed that dendrites and cell bodies of neurons are the tissue components primarily affected in brain damage induced by monosodium glutamate.

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