Sweat in Schizophrenic Patients: Identification of the Odorous Substance

Science  17 Oct 1969:
Vol. 166, Issue 3903, pp. 398-399
DOI: 10.1126/science.166.3903.398


The substance causing the peculiar odor in sweat of schizophrenic patients has been isolated and identified as trans-3-methyl-2-hexenoic acid by gas chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy. The natural and the synthetic compounds were cleaves across the double bond to give 2-pentanone and oxalic acid, thereby confirming the structure.