Reports

Carcinogen-Induced Immune Depression: Absence in Mice Resistant to Chemical Oncogenesis

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Science  31 Oct 1969:
Vol. 166, Issue 3905, pp. 620-621
DOI: 10.1126/science.166.3905.620

Abstract

Administration of 3-methylcholanthrene 6 days before antigenic challenge depressed the immune response to sheep red cells in young adult mice (C3Hf/Bi strain) sensitive to the oncogenic effect of the drug (100 percent local tumors 240 days after carcinogen). The drug was not immunodepressant in the I strain, which is relatively resistant to its carcinogenic effect (11 percent local tumors 240 days after carcinogen).

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