Alcohol Metabolism: Role of Microsomal Oxidation in vivo

Science  31 Oct 1969:
Vol. 166, Issue 3905, pp. 627-628
DOI: 10.1126/science.166.3905.627


A role for microsomal alcohol oxidation cannot be demonstrated in vivo. Factors affecting microsomal drug hydroxylations had no effect on alcohol metabolism in the rat in vivo. The compound SKF 525-A which inhibits, and chronic phenobarbital treatment which enhances microsomal drug hydroxylations did not alter alcohol oxidation.