Induction of Helical Arrays of Ribosomes by Vinblastine Sulfate in Escherichia coli

Science  07 Nov 1969:
Vol. 166, Issue 3906, pp. 768-769
DOI: 10.1126/science.166.3906.768


Physiological concentrations of vinblastine sulfate elicited ribosomal helices in large numbers in growing cultures of the osmotically sensitive mutant sud 24 and, after treatment with ethylenediaminetetraacetate, also in the K-12 strain. The helices were usually seen at the division plane and were often connected to the membrane. This method of induction of ribosomal helices offers a unique system for studying in vivo structure and function of the translational apparatus in relation to other cell components.