Hepatic Influence on Splenic Synthesis and Release of Coagulation Activities

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Science  14 Nov 1969:
Vol. 166, Issue 3907, pp. 882-883
DOI: 10.1126/science.166.3907.882


Isolated rabbit liver perfusates contain one or more puromycinsensitive factors that stimulate factor VIII and IX activities in splenic perfusates. Production of coagulation activity by a complementary process involving organ perfusates suggests existence of coagulation factor precursors. An analogy is made to appearance of high factor VIII activity after plasma transfusions in von Willebrand's disease.