Reports

Immune Response in vitro: Independence of "Activated" Lymphoid Cells

Science  21 Nov 1969:
Vol. 166, Issue 3908, pp. 1002-1004
DOI: 10.1126/science.166.3908.1002

Abstract

Antibody formation against sheep erythrocytes by mouse spleen cells in vitro requires interactions among antigen-treated macrophages and lymphoid cells in cell culsters for only a finite time. During this critical period of interaction, lymphoid cells become "activated" and thereafter can develop into antibody-producing cells independently of native antigen, macrophages, and cell clusters.

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