Polyol Pathway in Aorta: Regulation by Hormones

Science  21 Nov 1969:
Vol. 166, Issue 3908, pp. 1007-1008
DOI: 10.1126/science.166.3908.1007


Aldose reductase is present in human and rabbit aortas and provides a mechanism whereby hyper-glycemia can alter the metabolism of the arterial wall. Aortic sorbitol concentration is regulated by ambient glucose concentration and is increased by epinephrine, isoproterenol, dibutyryl-3',5'-adenosine monophosphate, ouabain, and angiotensin II.