Intestinal Calcium Absorption: Nature of Defect in Chronic Renal Disease

Science  28 Nov 1969:
Vol. 166, Issue 3909, pp. 1154-1156
DOI: 10.1126/science.166.3909.1154


When compared to that of normal animals, calcium-binding protein activity of duodenal mucosa obtained from uremic rats was decreased. There was no change in this activity after vitamin D3, therapy. In contrast, prior treatment with 25-hydroxycholecalcijerol resulted in increased transport of calcium-45 and calcium-binding protein activity in the intestine.