Hypobaric Hypoxia: Effects on Early Development of Tryptophan Oxygenase in Neonatal Rats

Science  12 Dec 1969:
Vol. 166, Issue 3911, pp. 1412-1413
DOI: 10.1126/science.166.3911.1412


Despite a reduction in liver and body weights of neonatal rats born and reared at a simulated altitude of 5790 meters (oxygen pressure, 76.36 millimeters of mercury), the hepatic enzyme tryptophan oxygenase develops prematurely in these stressed animals as compared to controls reared at sea level. Also, the specific activities remain distinctly elevated through the first 9 days of age; thus, the competence for premature synthesis ot tryptophan oxygenase is confirmed in neonatal rats.