Prostaglandins E1 and E2 Antagonize Norepinephrine Effects on Cerebellar Purkinje Cells: Microelectrophoretic Study

Science  12 Dec 1969:
Vol. 166, Issue 3911, pp. 1418-1420
DOI: 10.1126/science.166.3911.1418


In microelectrophoretic experiments, prostaglandins E1 and E2 antagonize the reduction in discharge rate of cerebellar Purkinje cells produced by norepinephrine. Slowing of discharge evoked by 3',5'-adenosine monophosphate or gamma aminobutyric acid is not antagonized. These data provide the first indication that endogenous prostaglandins may physiologically function to modulate central noradrenergic junctions.