Amino Acid Uptake by Kidney and Jejunal Tissue from Dogs with Cystine Stones

Science  19 Dec 1969:
Vol. 166, Issue 3912, pp. 1525-1527
DOI: 10.1126/science.166.3912.1525


Cystine and lysine accumulation in vitro in intestinal and renal tissue was studied in eight dogs that form cystine stones. Under conditions which demonstrate in vitro defects in tissue obtained from humans with cystinuria, normal amino acid accumulation occurred in six dogs with the canine disorder. Normal amino acid uptake in tissue and the demonstration of normal to minimum increases in excretion of lysine suggest that the canine disorder is not similar to the human syndrome.