Reports

Local Anesthetics: Significance of Hydrogen Bonding in Mechanism of Action

Science  19 Dec 1969:
Vol. 166, Issue 3912, pp. 1546-1548
DOI: 10.1126/science.166.3912.1546

Abstract

The action of local anesthetics is considered in terms of their ability to function as the donor in a hydrogen bond. The formation of a hydrogen-bonded complex between the drug and an acceptor group on the neural membrane is suggested as a feature in the action of local anesthetics.

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