Reports

Ligand-Induced Maturation of Threonine Deaminase

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Science  02 Jan 1970:
Vol. 167, Issue 3914, pp. 75-76
DOI: 10.1126/science.167.3914.75

Abstract

The dimeric intermediate substructures of threonine deaminase, which are obtained by alkaline dialysis of the native tetrameric enzyme, are inactive after reassembly unless they are subsequently exposed to maturation-inducing ligands for which the enzyme possesses stereospecific binding sites. The binding of the ligands at these sites precedes the full maturation of the enzyme.