Dentin Matrix Transformation: Rapid Induction of Alkaline Phosphatase and Cartilage

Science  06 Feb 1970:
Vol. 167, Issue 3919, pp. 896-898
DOI: 10.1126/science.167.3919.896


An acid-insoluble fraction of rat dentin rapidly initiates a chain reaction in mesenchyma after allogeneic transplantation to the subcutaneous tissues. The tooth matrix induced alkaline phosphatase activity within 24 hours; cartilage appeared within 5 days; bone and bone marrow formed within 14 days. The induced cartilage disappeared within 5 weeks, but bone persisted at least 1 year.