Reports

Bladder Cancer Induction by Aromatic Amines: Role of N-Hydroxy Metabolites

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Science  13 Feb 1970:
Vol. 167, Issue 3920, pp. 992-993
DOI: 10.1126/science.167.3920.992

Abstract

Repeated installation of N-hydroxy-2 naphthylamine into dog bladders produced tumors of this organ. There is a correlation of degree of carcinogenicity of 1-naphthylamine, 2-naphthylamine, and 4-aminobiphenyl with both methemoglobin production in the blood and concentration of N-oxidation products in the urine. Thus, N-hydroxylation appears to be the key to bladder cancer production by aromatic amines.