Hyperbaric Oxygen: Effects on Metabolism and Ionic Movement in Cerebral Cortex Slices

Science  13 Mar 1970:
Vol. 167, Issue 3924, pp. 1508-1510
DOI: 10.1126/science.167.3924.1508


The incubation of slices of cerebral cortex under hyperbaric oxygen pressures from 1 to 10 atmospheres in the presence of radioactive glucose, pyruvate, succinate, fumarate, L-glutamate, and gamma-aminobutyric acid causes a marked diminution of tissue oxidative reactions. There is a simultaneous decrease in phosphocreatine and adenosine triphosphate, and a reduction of the apparent intracellular ionic gradients. The increase of lipid peroxides, measured directly, is attributed to the toxic effects of hyperbaric oxygen.