Hydroxyurea: Suppression of Two-Stage Carcinogenesis in Mouse Skin

Science  03 Apr 1970:
Vol. 168, Issue 3927, pp. 130-132
DOI: 10.1126/science.168.3927.130


Hydroxyurea, a selective cytotoxic agent for cells in DNA synthesis, injected intraperitoneally at 24 and 48 hours after the first painting with 1 percent croton oil, significantly reduced the tumor yield in the two-stage chemical carcinlogenesis in mouse skin. A comparable group of mice receiving hydroxyurea only once at 24 hours had a tumor induction similar to that in controls.