Mixed Lymphocyte Cultures Produce Effector Cells: Model in vitro for Allograft Rejection

Science  03 Apr 1970:
Vol. 168, Issue 3927, pp. 133-135
DOI: 10.1126/science.168.3927.133


Mouse peripheral lymphocytes sensitized in vitro by culturing with allogeneic lymphocytes produced immunospecific destruction of target cells, as measured by release of chromium-51. Thus the sensitizing and effector phases of the cell-bound immune response can both be studied in an in vitro system.