Histochemical Abnormalities of Skeletal Muscle in Patients with Acute Psychoses

Science  10 Apr 1970:
Vol. 168, Issue 3928, pp. 273-275
DOI: 10.1126/science.168.3928.273


In 29 acutely psychotic patients (mostly schizophrenic), histochemical abnormalities of a myopathic type were demonstrated in skeletal muscle biopsies from 13 and were generally correlated with elevation of the "muscle" type isoenzymes of creatine phosphokinase in the patients' serum. The incidence was much higher than found in normal controls, hospitalized neurotic psychiatric patients, or parents of acutely psychotic patients. A diazo-coupling type of "alka-line phosphatase" reaction was particularly useful in identifying abnormal muscle fibers.