Hormone-Sensitive Adenyl Cyclase: Cytochemical Localization in Rat Liver

Science  17 Apr 1970:
Vol. 168, Issue 3929, pp. 382-384
DOI: 10.1126/science.168.3929.382


An electron microscopic procedure has been developed, using rat liver, for the localization of hormone-sensitive adenyl cyclase. Isoproterenol-sensitive adenyl cyclase is located almost exclusively in the parenchymal cells. In contrast, glucagon-sensitive adenyl cyclase is located primarily in the reticulo-endothelial cells but is also present in parenchymal cells. Sodium fluoride-sensitive adenyl cyclase is found in both cell types.