Reports

DDT Metabolism: Oxidation of the Metabolite 2,2-bis(p-Chlorophenyl) ethanol by Alcohol Dehydrogenase

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Science  01 May 1970:
Vol. 168, Issue 3931, pp. 582
DOI: 10.1126/science.168.3931.582

Abstract

A metabolite of DDT, 2,2-bis(p-chlorophenyl)ethanol, is a substrate of crystalline liver alcohol dehydrogenase. The oxidation of the substrate was detected spectrophotometrically. The p-nitrophenylhydrazone derivative of the product, 2,2-bis(p-chlorophenyl)acetaldehyde, was identified by comparing its mass spectrum and thin-layer chromatographic behavior with that of an authentic sample.