Reports

l-Glutamic Acid Decarboxylase: A New Type in Glial CelLs and Human Brain Gliomas

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Science  01 May 1970:
Vol. 168, Issue 3931, pp. 598-599
DOI: 10.1126/science.168.3931.598

Abstract

Human glial cells grown in culture and gliomas and white matter contain an l-glutamic acid decarboxylase which is stimulated markedly by carbonyl-trapping agents. In contrast, L-glutamic acid decarboxylase activity of human cerebral gray matter is strongly inhibited by carbonyl-trapping agents. These results suggest a glial localization of the new type of l-glutamic acid decarboxylase.