On the Apparent Homology of Actin and Tubulin

Science  15 May 1970:
Vol. 168, Issue 3933, pp. 845-847
DOI: 10.1126/science.168.3933.845


Muscle actin and ciliary A-tubulin from Pecten irradians have molecular weights of 46,000 and 59,000, respectively, as measured by sodium lauryl sulfate—polyacrylamide-gel electrophoresis. Tryptic and chymotryptic peptides obtained from these proteins are very dissimilar, indicating that there is little significant homology.