Ochratoxin A: Inhibition of Mitochondrial Respiration

Science  29 May 1970:
Vol. 168, Issue 3935, pp. 1102-1103
DOI: 10.1126/science.168.3935.1102


Ochratoxin A is a fungal metabolite which induces pathological changes in animals. The toxin was isolated from cultures of Aspergillus ochraceus and purified by thin-layer chromatography. Ochratoxin A and one of its hydrolysis products, dihydroisocoumarin, severely inhibited coupled respiration when applied at low concentration to rat liver mitochondria.