Alcohol Aversion in the Rat: Behavioral Assessment of Noxious Drug Effects

Science  05 Jun 1970:
Vol. 168, Issue 3936, pp. 1244-1246
DOI: 10.1126/science.168.3936.1244


Injections of p-chlorophenylalanine or n-butyraldoxime given after rats were first given a 10-minute drinking test with saccharin or ethanol solutions produced a learned aversion to these solutions. These findings suggest that the reduced self-selection of alcohol (preference) resulting from the administration of these drugs, reported by others, is not specifically alcohol-related. The technique described offers a sensitive procedure for the assessment of unpleasant effects of drugs.