Morphine: Radioimmunoassay

Science  12 Jun 1970:
Vol. 168, Issue 3937, pp. 1347-1348
DOI: 10.1126/science.168.3937.1347


The development of a radioimmunoassay for morphine is described.The hapten morphine is made antigenic by coupling it to a protein at the phenolic group of the molecule. Extremely low concentrations of morphine (0.5 nanogram) can be measured by this assay procedure.